Harvard symbologist Robert Langdon awakens in a Florence hospital with no memory of the past 36 hours and a cryptic object in his possession. He teams up with Dr. Sienna Brooks to unravel a puzzle linked to Dante Alighieri’s Divine Comedy. Their quest leads them through Italy and beyond, racing against time to prevent the release of a devastating plague. As they decode clues hidden in Renaissance art and architecture, Langdon and Sienna confront a radical vision for humanity's future, challenging the ethics of genetic engineering and population control.